Season 2
20 episodes · Oct 13, 2025
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S2E1A Son in the Oven
Oct 13, 202543mWatson and the fellows spring back into action when Mary’s mother accidentally poisons herself while suffering from a rare form of dementia that is progressing with impossible speed. Meanwhile, Sherlock Holmes resurfaces after being presumed dead.
S2E2Back from the Dead
Oct 20, 202543mA microbiology researcher returns from an expedition to Siberia, leading to a possible outbreak of a revived pathogen. Watson reconnects with Sherlock Holmes.
S2E3Expletive Deleted
Oct 27, 202543mWatson and the team work alongside Laila to help a patient named Maxine, a 30-year-old who looks 10 years old.
S2E4Happy When It Rains
Nov 3, 202543mWatson and the team jump into action when four new patients are brought to UHOP with wounds that appear to be infected with a flesh-eating bacterium following a tornado. Meanwhile, Shinwell searches for meaning as a nursing student and Adam’s wedding to Lauren risks being halted.
S2E5Lucky
Nov 10, 202543mWhile visiting another hospital, Watson becomes convinced that a coma patient is suffering from locked-in syndrome and has been mistaken for a coma patient for over a decade. After the patient is transferred to UHOP for treatment, he shocks the team with chilling messages. Meanwhile, Sherlock is back in town and is staying with Watson.
S2E6Buying Time
Nov 17, 202543mWatson and the fellows race against time to save the life of Xavier, a 21-year-old athlete with a fast-growing, seemingly incurable cancer. Meanwhile, Mycroft Holmes lets Watson know his team’s work at UHOP may no longer have funding available.
S2E7Giant Steps
Nov 24, 202543mWatson's father, Hamish, visits UHOP to introduce Watson and the fellows to his protégé, Annabelle, a saxophone prodigy with musically induced blackouts. As Annabelle's condition worsens, Watson must confront his long-standing tensions with his father in order to save her.
S2E8Livvy Sees the Doctor
Dec 1, 202543mUHOP veers into terror when Watson and the fellows are taken hostage by a man with a bomb strapped to his chest who is desperate to find a cure for his 9-year-old daughter’s illness.
S2E9Shannon Says Bex Loves Micah
Dec 8, 202543mWatson and the fellows help Laila’s son Micah – who was injured in a car accident while pursuing his crush, Bex, with the help of his AI chatbot.
S2E10Never Been CRISPR'd
Dec 15, 202543mWatson’s biohacker friend Hobie returns when he rushes his new girlfriend to the Holmes Clinic after they partake in a gene-editing experiment that goes wrong. Meanwhile, Watson becomes suspicious of Sherlock.
S2E11The Tunnel Under the Elms
Mar 1, 202643mWatson and the fellows race against the clock to save a man and his pregnant wife from a terrifying sinkhole. Meanwhile, Ingrid’s future with her therapy group becomes unclear.
S2E12A Family Meal
Mar 8, 202643mWhen a patient arrives at the Holmes Clinic plagued by a mysterious neurological disorder, Watson and the fellows discover they were forced to eat their parents amid a childhood survival incident. Meanwhile, Adam is struggling with how his future will change as a father.
S2E13For a Limited Time Only
Mar 15, 202643mWatson and the fellows fight to revive a 30-year-old woman, Audrey, after her heart inexplicably stops repeatedly until they discover she has a rare phenomenon called Lazarus syndrome. As these revivals continue, she uses the short window of time available to right her greatest wrong.
S2E14Wrongful Life
Mar 22, 202643mWatson is sued for Wrongful Life by a long-term patient suffering from VACTERL association, after undergoing multiple painful surgeries.
S2E15A Third Act Surprise
Mar 29, 202643mWatson and the fellows race to save the life of a young woman who needs a lifesaving kidney donation. Meanwhile, Sherlock returns to help crack unsolved cases in Pittsburgh.
S2E16Respect the Process. Respect the Quirks
Apr 5, 202643mWatson investigates a case involving a mentally unstable mother, with the woman's delusions serving as a mirror to his own newly discovered hallucinations.
S2E17Unsolved Mysteries
Apr 12, 202643mIn the wake of the car accident, Watson and Laila lie injured and awaiting rescue as the team races to find them before it’s too late. Meanwhile, in a state between life and death, Watson’s mind plays out a modern-day investigation of a case that has long haunted him.
S2E18Sic Semper Tyrannis
Apr 19, 202643mFollowing his brain tumor diagnosis, Watson goes on medical leave to seek treatment, leaving Mary in charge of The Holmes Clinic as a notorious South American dictator demands Watson see to his mysterious autoimmune condition personally. Meanwhile, Ingrid grows more concerned about Beck’s obsession with Sasha.
S2E19Rule of Three
Apr 26, 202643mAs Adam's wife goes in for a C-section to deliver triplets, chaos ensues when their OB-GYN passes out in the operating room. Meanwhile, a severe storm detours Watson and Mary's trip to find a renowned doctor to remove Watson's brain tumor.
S2E20The Cobalt Fissure
May 3, 202644mA seemingly random murder outside of UHOP sets the stage for the arrival of someone from Watson and Sherlock Holmes' past.